This chart indicates that now could be a good time to sell. But Holochain has strong design fundamentals that place it at a strong advantage over blockchains. Personally, I would say that the bull market in crypto is going to keep running for maybe a year, and that Holochain is making good progress, so I certainly wouldn't sell off 100% of HOT tokens. Maybe take some profits or set price alerts or stop losses, but I suggest to continue holding most of your tokens. Its still in a closed alpha testnet so there will be huge room for growth as it goes to an open main net, with a growing ecosystem of apps being built on Holochain and using Holo.
Not investment advice, DYOR